Assistant Professor, Department of Organic Chemis¬try, Pharmaceutical Faculty, Semmelweis University, Budapest, Hungary

Biography: Péter Tétényi graduated from the Pharmaceutical Faculty, Semmelweis Medi¬cal University, Budapest, Hungary. He dealt with synthetic drug research after graduation at the Pharmaceutical Works Gedeon Richter, Budapest, Hungary. He had a one-year postdoc¬torate fellowship with Professor S.L. Regen at the Chemistry Department, Milwaukee, Wis¬consin, U.S. He completed his Ph.D. research in 1993 in the field of polymer supported syn¬theses. He has educated Hungarian and English language students to Organic chemistry at the Department of Organic Chemis¬try since 1990. He participated assembling 5 patents, 6 artic-les, and he wrote 2 own chapters for American polymer books, among them one chapter was published, the other was rejected without reasoning. He was always interested in exploring quite unknown areas and breaking as many rules as he could.

Speech Title: Fighting with scientific dogmas in polymer supported syntheses.

Aims: Elaboration of sequential synthesis of carbon chains on polymer support.

Methods: Each step was carried out by magnetic stirring with 400-800 rpm. Ex¬traction, drying and distillation was applied for purification of the cleaved compounds. Checking polymers happened by FTIR, as well as by FTIR and NMR for the cleaved compounds. The cleaved polymers were reused many times. New characterization of swelling of polymers was developed.

Results: Introduction of a new aryl alkyl ether linker with sufficient stability, under preparative conditions. The attachment of the first C₂ unit took part in protic solvents. Reduction of the carboxylic acid functional group was carried out by mixture of NaBH₄ and AlCl₃ in ratio of 3 to 1. Halogenation mixture consisting of thionyl chlo¬ride, water and pyridine in ratio of 2:1:2 was developed for the OH – Cl substitution, in order to increase concentration of Cl- within the poly¬mer beads. The alkylation of polymer supported aliphatic halides is carried out with various C-H acids, as well as with metal salts of heterocycles. Further deethoxycarbonylation step was used for direct removal of the ester group at enormously low temperature. Cleavage of the substrates was executed by Lewis acids.

Conclusions: The new linker proved to be much better, than the similar benzyl ether linkers, based on the swelling results. 6 scientific dogmas were refuted.